Table 1. Summary of in vivo parameters.
Age | 1 month | 2 months | 3 months | |||
WT | DCM | WT | DCM | WT | DCM | |
BW (g) | 12.8±0.9 | 13.3±0.6 | 21.4±0.6 | 21.7±0.8 | 23.2±1.0 | 22.7±0.7 |
N | 8 | 8 | 18 | 13 | 11 | 16 |
ECG recording (anesthetized) | ||||||
HR (bpm) | 355±27 | 430±25* , a | 392±18 | 394±37 | ND | ND |
PR (ms) | 35±1 | 33±1 | 38±2 | 38±2 | ND | ND |
QRS (ms) | 9.6±0.3 | 10.3±0.3 | 11.0±0.3 | 16.7±0.6* | ND | ND |
QT (ms) | 34±1 | 42±2* | 36±1 | 53±1* | ND | ND |
N | 6 | 6 | 6 | 6 | - | - |
ECG recording (conscious) | ||||||
HR (bpm) | 740±16 | 773±15 | 721±10 | 700±6 | 726±9 | 698±17 |
PR (ms) | 29.1±0.9 | 29.6±0.8 | 33.6±0.7 | 33.0±1.1 | 34.7±0.8 | 33.8±1.6 |
QRS (ms) | 9.9±0.4 | 12.3±0.4 | 10.1±0.4 | 15.9±0.9** | 10.1±0.1 | 16.9±1.4** |
QT (ms) | 17.1±0.4 | 23.3±0.9** | 17.0±0.5 | 33.8±1.9** | 18.5±0.6 | 37.9±2.2** |
N | 5 | 6 | 5 | 6 | 5 | 5 |
Data are means ± SEM.
P<0.05,
P<0.01 vs. WT. BW: body weight. ND: not determined.
: The significant difference from WT mice is probably due to a difference in depth of anesthesia.