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. 2012 Apr 13;7(4):e35353. doi: 10.1371/journal.pone.0035353

Table 1. Summary of in vivo parameters.

Age 1 month 2 months 3 months
WT DCM WT DCM WT DCM
BW (g) 12.8±0.9 13.3±0.6 21.4±0.6 21.7±0.8 23.2±1.0 22.7±0.7
N 8 8 18 13 11 16
ECG recording (anesthetized)
HR (bpm) 355±27 430±25* , a 392±18 394±37 ND ND
PR (ms) 35±1 33±1 38±2 38±2 ND ND
QRS (ms) 9.6±0.3 10.3±0.3 11.0±0.3 16.7±0.6* ND ND
QT (ms) 34±1 42±2* 36±1 53±1* ND ND
N 6 6 6 6 - -
ECG recording (conscious)
HR (bpm) 740±16 773±15 721±10 700±6 726±9 698±17
PR (ms) 29.1±0.9 29.6±0.8 33.6±0.7 33.0±1.1 34.7±0.8 33.8±1.6
QRS (ms) 9.9±0.4 12.3±0.4 10.1±0.4 15.9±0.9** 10.1±0.1 16.9±1.4**
QT (ms) 17.1±0.4 23.3±0.9** 17.0±0.5 33.8±1.9** 18.5±0.6 37.9±2.2**
N 5 6 5 6 5 5

Data are means ± SEM.

*

P<0.05,

**

P<0.01 vs. WT. BW: body weight. ND: not determined.

a

: The significant difference from WT mice is probably due to a difference in depth of anesthesia.