Figure 7. Pretreatment with fenofibrate for 2 days is not protective against JEV infection, in vivo, in mice.

(A,B) Fenofibrate administered 2 days prior to JEV challenge has no effect on the mortality and viral titers in JEV infected animals. (C) mRNA expression of TNF-α, IL-6, MCP-1, IL-1β were unchanged in fenofibrate pretreated mice compared to those exposed to JEV alone. Insets in C show that cytokines and chemokine after fenofibrate treatment alone also were unchanged. Data is represented as (C) vehicle control, (F) fenofibrate, (J) JEV, (F+J) fenofibrate+JEV treated mouse brain cortex. mRNA levels in A,B for all treatments are expressed relative to controls (n = 8 per group, *and #p<0.05).