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. 2012 Apr 13;7(4):e34016. doi: 10.1371/journal.pone.0034016

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Kim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Wild-type thorax and notum bears macrochaetes at specific positions (circles, A). Extra macrochaetes indicated by arrowheads are produced in transheterozygous pum mutants, pum¹⁶⁸⁸/pum³ (B), pum³/pum^Msc (C), pum¹/pum^Msc (D), and pum^Msc/pum¹⁶⁸⁸ (E). Extra macrochaetes arose by ectopic expression of EGFR in SOP (sca-GAL4/+; UAS-EGFR/+) (F). One copy reduction of pum greatly increased extra macrochaetes induced by enhanced EGFR signaling in SOP (sca-GAL4/+; UAS-EGFR/pum¹⁶⁸⁸) (G) and (sca-GAL4/+; UAS-EGFR/pum^Msc) (H). Ectopic expression in SOP of full-length pum (sca-GAL4/UAS-pum) (I) or Puf (C253-GAL4/UAS-Pum^HD) (K) eliminated macrochaetes. Concomitant expression in SOP of EGFR with either pum (sca-GAL4/UAS-Pum; UAS-EGFR) (J) or Puf (C253-GAL4/UAS-Pum^HD; UAS-EGFR) (L) eliminated bristles. The number of macrochaetes circled in (A) was counted (M, N). ***; P value <0.001. **; P value <0.01. The P values were obtained by student’s t-test in SigmaPlot.