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. 2012 Apr 13;7(4):e33247. doi: 10.1371/journal.pone.0033247

Figure 1. Immunohistochemistry of nNOS in the MPOA and PVN following three weeks of antipsychotic drug administration.

Figure 1

nNOS immunostaining in the MPOA (A) and the PVN (D); Quantitative analyses of nNOS positive cell density in the MPOA (B) and the PVN (E), Haloperidol significantly decreased the nNOS positive cell density in the ADP; Quantitative analyses of nNOS IOD in the MPOA (C) and the PVN (F). Haloperidol significantly decreased nNOS IOD in MPN and ADP, and risperidone inhibited the nNOS IOD in the ADP. 3 v: third ventricle; ac: anterior commissure; ADP: anterodorsal preoptic nucleus; ox: optic chiasma; IOD: integrated optical density; MPN: medial preoptic nucleus. Scale bar:200 µm. *p<0.05 vs Vehicle.