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. 2012 Apr 13;7(4):e34773. doi: 10.1371/journal.pone.0034773

Table 1. Oral cancer-free survival (OCFS) analysis of risk factors in transformation of oral leukoplakia.

Characteristic Malignant events/n OCFS rate at 3 yr (SE) OCFS rate at 5 yr (SE) P
All patients 57/320 0.866 (0.024) 0.820 (0.029)
Gender 0.141
Female 37/175 0.865 (0.032) 0.814 (0.039)
Male 20/145 0.867 (0.037) 0.830 (0.044)
Age (yr) 0.021
< = 60 38/228 0.880 (0.027) 0.849 (0.031)
>60 19/92 0.827 (0.052) 0.726 (0.071)
Lesion site <0.001
Other sites 19/199 0.920 (0.024) 0.880 (0.032)
Lateral/ventral tongue 38/121 0.789 (0.046) 0.735 (0.052)
Lesion type 0.001
Homogenous 49/301 0.877 (0.024) 0.842 (0.029)
Non-homogenous 8/19 0.697 (0.116) 0.542 (0.132)
Epithelial dysplasia <0.001
Low grade 27/229 0.937 (0.020) 0.905 (0.026)
High grade 30/91 0.675 (0.065) 0.590 (0.073)
Smoking 0.423
Never 33/194 0.868 (0.031) 0.816 (0.039)
Past and present 11/86 0.888 (0.044) 0.888 (0.044)
Unknown 13/40
Alcohol intake 0.689
Never 32/196 0.875 (0.031) 0.835 (0.037)
Past and present 12/84 0.876 (0.045) 0.847 (0.052)
Unknown 13/40

SE, standard error of the mean.