The Bcd, Hb, and Kr network. a Bcd, Hb, and Kr network interactions that were simulated. Bcd activates transcription of Hb and Kr. Hb and Kr mutually repress each other. b Expression pattern of the Bcd gradient and Hb and Kr regions following the network design described in Fig. 5a. Activation of Kr by Bcd is greater than Hb activation, while Kr repression by Hb is stronger than the reciprocal repression of Hb by Kr