. 2012 Mar 27;14(2):352–364. doi: 10.1208/s12248-012-9344-7

Table III.

Physiological and Kinetic Parameters for Mitoxantrone PBPK Simulations in Humans

Organ	Blood flow rate (L/min)^a	Organ volume (L)^a	DNA concentration (μM)^b	Protein concentration (μM)^c
Plasma	5.6	3
Lung	5.6	1.17	15^d	19
Heart	0.24	0.31	8.3	43.8
Spleen	0.077	0.192	15^d	3.54
Liver	1.45	1.69	23.7	514
Kidney	1.24	0.28	16.2	52.3
Brain	0.7	1.45	0.1	–
Other	1.893	62	4.5^d	4.67

These parameters were fixed for our simulations of mitoxantrone PK in humans

^aThe blood flow rate and organ volume in each tissue were obtained based on a 70-kg man from literature data (25)

^bDNA content were taken from Gustafson et al. (17)

^cProtein content (T _macro) in different tissues were assumed to be identical among mammals and values were fixed using values obtained from mouse mitoxantrone PBPK model 3

^dHuman lung and spleen DNA contents used in the simulations were the literature reported human DNA content in rapidly perfused organs. DNA content in the remainder compartment used in the simulations was the reported DNA content in slowly perfused organs (17). DNA content in the brain used in the simulations was the value obtained from the mouse mitoxantrone PBPK model 3