Table I.

Instruments and Manufacturer Specifications for Particle Sizing/Counting Measurements

Method	Manufacturer	Capabilities
		Size range	Max count	Volume required
		(μm)	(#/mL)	(mL)
Light obscuration	HIAC-Royco	2–100	18,000	5
MFI—high magnification	Brightwell	0.75–100	825,000	2
MFI—low magnification	Brightwell	2.25–400	275,000	1
Coulter–Counter	Beckman Coulter Instruments	0.4–12, 2–60	1 × 106	10
Laser diffraction	Particle Measuring System	0.02–2.0	10,000	5
	Microtrac Bluewave	0.1–2.0	N/A	7
	Beckman Coulter LS320	0.04–2.0	N/A	10
DLS	Brookhaven Instruments	0.01–4.0	N/A	0.5
	Wyatt Technology, Dynapro	0.002–1.0	N/A	0.05
Backscatter DLS	Microtrac Nanotrac	0.001–6.5	N/A	0.5

MFI micro-flow imaging, N/A not applicable, DLS dynamic light scattering