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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Invest Dermatol. 2012 Feb 9;132(5):1363–1373. doi: 10.1038/jid.2011.472

Figure 4. Surrogate gene expression biomarkers of MRSS.

Figure 4

A. Probes that matched the 177 genes with correlations above |0.5| from Milano were extracted from the “by patient” intrinsic analysis resulting in 44 genes. Hierarchical clustering results in two groups. Group 1 (red branches) includes dSSc and healthy control skin biopsies, while group 2 (black branches) includes primarily dSSc skin biopsies. The first row below the dendrogram, bars indicate the intrinsic subset assignment in the ‘by patient’ analysis (normal-like, green; diffuse1, blue; diffuse2, red; inflammatory, purple; unclassified, black). The second row indicates sample diagnosis, dSSc (red) or healthy control (black). B. Comparison of MRSS between the two groups shows a statistically significant difference in MRSS (two sample t-test, p = 0.005).