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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Kidney Int. 2012 Jan 25;81(9):880–891. doi: 10.1038/ki.2011.469

Figure 8. Id1 deficiency reduces RANTES and TNF-α expression in obstructive nephropathy in vivo.

Figure 8

(a, b) RT-PCR results show that Id1 deficiency decreased renal RANTES and TNF-α mRNA expression at 7 d after UUO. (a) representative RT-PCR data; (b) graphic presentation of relative RANTES and TNF-α mRNA levels detected by quantitatively, real-time PCR. *P < 0.05 (n =6). (c, d) RANTES is induced in the degenerated tubules of obstructed kidneys at 7 d after UUO, which is attenuated in Id1 knockout mice. Kidney sections were immunostained with anti-RANTES antibody. Arrow shows the RANTES-positive tubules. Scale bar, 50 μm. (c) representative micrographs; (d) quantitative determination of RANTES protein expression in various groups as indicated. *P < 0.05 (n =6).