Table 4.

Odds ratios (and 95% CIs) of NMSC, BCC, and SCC according to ERCC6 haplotypes (rs2228527, rs4838518, rs2228529).

Haplotype	Frequency case/control	NMSC OR (95% CI)	Frequency BCC cases	BCC OR (95% CI)	Frequency SCC cases	SCC OR (95% CI)
AGA AAA AAG GGA GAG	50.3/52.0 28.2/29.0 0.1/0.1 0.4/0.3 20.9/18.5	1.0 (referent) 1.11 (0.87 – 1.41) 1.28 (0.09 – 17.73) 1.88 (0.35 – 10.14) 1.63 (1.23 – 2.16)	49.3 29.0   0.1   0.4 21.0	1.0 (referent) 1.24 (0.94 – 1.63) 1.60 (0.12 – 21.80) 2.08 (0.35 – 12.28) 1.94 (1.40 – 2.67)	50.7 27.1   0   0.5 21.7	1.00 (referent) 0.94 (0.59 – 1.49) -- 0.71 (0.05 – 10.74) 1.07 (0.64 – 1.80)
Overall p-value		0.03		<0.01		0.99

Abbreviations: CI, confidence interval; OR, Odds ratio

All models were adjusted for the first three principle components, and baseline age, education, body mass index, and smoking

Six of the possible eight haplotypes were observed, with one occurring only among controls (GAA, n = 2)

Numbers do not add to 100 due to rounding