Fig. 5.

In vivo displacement of [¹⁸F]DPA-714 by injection of DPA-714 or PK11195 with 1 mg/kg (a) and 5 mg/kg (b), respectively. Graphs illustrate %ID/cc values before versus after administration of the unlabelled compound in tumour and control VOIs. Measurements for pre- and post-displacement were compared at 27.5 and 47.5 min after radiotracer injection, two time points with identical frames of PET data acquisition. [¹⁸F]DPA-714 uptake decreased significantly in the tumour VOI after displacement with DPA-714 at 1 mg/kg (**p < 0.01) and 5 mg/kg (***p < 0.001) or with 5 mg/kg PK11195 (*p < 0.05)