Figure 3.

(A) Expression levels of HD5 short hairpin RNA (shRNA: black bars) and CTRL5 short hairpin RNA (white bars) in tissue punches from the caudate (two per monkey, one per hemisphere, total n = 8 per group) and putamen (four per monkey, two per hemisphere, total n = 16 per group) of AAV2-HD5 or AAV2-CTRL5 recipients, relative to the minimum detectable amount by reverse transcription–polymerase chain reaction assay. Samples below the detection limit were assigned a value of zero as a raw score, and one as a log-transformed score. (B) Expression of huntingtin (Htt) messenger RNA levels in the same tissue punches and treatment groups (black bars = AAV2-HD5 recipients, white bars = AAV2-CTRL5 recipients) as a percentage of the average amount detected in monkeys receiving AAV2-CTRL5. **P < 0.015.