Fig. 2.

Multivariate adjusted cubic splines of death hazard ratios and their 95% confidence levels for all-cause mortality across the entire range of ESA dose in PD (a) and HD (b) patients. Models are adjusted for age, gender, race/ethnicity, ten pre-existing co-morbid conditions, history of tobacco smoking, categories of dialysis vintage, primary insurance, marital status, presence of diabetes, serum ferritin and iron saturation, body mass index, serum levels of albumin, total iron-binding capacity, creatinine, phosphorus, calcium, bicarbonate, blood white blood cell count and lymphocyte percentage.