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. 2011 Dec 5;40(7):2884–2897. doi: 10.1093/nar/gkr1066

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Schematic representation to illustrate the dual association of MeCP2 with different chromatin domains in the brain. Shown in the right is a magnified image of the interaction of MeCP2 within the nucleosome fraction. Methylation of DNA in the vicinity of the nucleosome (in the proximity of the entry and exit sites of the DNA) as well as histone PTMs (such as H3K27me₃) or histone variants may play a role in the interaction. Also shown is a site of interaction of the C-terminal tail of MeCP2 with the N-terminal of histone H2A.