Figure 4.
Aβ deposition is associated with degree of decline in local bilateral functional connectivity. A, B, Consensus bilateral functional connectivity maps generated for young (A) and older (B) APP/PS1 mice and young (E) and older (F) wild-type mice. C, G, Bilateral functional connectivity difference map between young and older APP/PS1 (C) and wild-type (G) mice. D, H, p values of C, G, plotted on a −log10 scale. Note that in C, G, positive values represent age-related decline, whereas negative values represent age-related increase in bilateral functional connectivity. White circles denote anatomical landmarks for image coregistration.