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. 2012 Apr 1;185(7):769–778. doi: 10.1164/rccm.201108-1548OC

Figure 5.

Figure 5.

The degree of sensitization to Mycobacterium tuberculosis (M.tb) is an important determinant in the MVA85A-induced T-cell response. (A) Association between size of tuberculin skin test (TST) induration, measured at screening, and the summed early secretory antigenic target (ESAT)-6 and culture filtrate protein (CFP)-10–specific T-cell response, measured before MVA85A vaccination by IFN-γ enzyme-linked immunospot (ELISPOT) assay. (B) Association between size of TST induration and the Ag85A-specific T-cell response before MVA85A vaccination. (C) Association between the Ag85A-specific T-cell response before and 7 days after MVA85A vaccination. (D) Association between the Ag85A-specific T-cell response before and 1 year (364 d) after MVA85A vaccination. For (A–D), data from participants in all four groups were combined. Correlations were assessed by Spearman correlation test.