Figure 1.

Airway hyperresponsiveness (Penh) values during a methacholine (Mch) challenge consisting of successive exposures to (A) 0, 2.5, 5, 10, and 20 mg/ml Mch for BALB/c mice or (B) 0, 3.75, 7.5, 15, and 30 mg/ml Mch for C57BL/6 mice at the indicated day after intratracheal Pneumocystis inoculation. Mock-infected mice were given intratracheal inoculation of lung homogenates from uninfected SCID mice, and had significantly lower Penh values at the highest dose (*P < 0.05). Values are means ± SEM, n = 4–5, representative of three or more independent experiments.