Table 1.
Known substrates and confirmed other substrates of Syk in DG75
| Substrate | Site of phosphorylation | Reference | |
| Known substrates identified in B cells | |||
| HPK1 | LSESSDDDyDDVDIP | Y381 | (33) |
| BLNK | LLEDEADyVVPVEDN | Y178 | (34) |
| BTK | RYVLDDEyTSSVGSK | Y550 | (35) |
| GCET2 | GNSAEEYyENVPCKA | Y107 | (36) |
| HS1 | EPEPENDyEDVEEMD | Y378 | (37) |
| LAT | EDEESEDyQNSASIH | Y193 | (38) |
| PLCG1 | IGTAEPDyGALYEGR | Y771 | (39, 40) |
| TUBA | MAALEKDyEEVGVDS | Y432 | (41) |
| Syk | LPMDTEVyESPYADPTEVYESPyADPEEIR | Y348Y352 | (42) |
|
Confirmed new Syk substrates in B cells | |||
| MAPRE1 | FFDANYDGKDyDPVAAR | Y124 | |
| NUCKS | SQFQESDDADEDyGR | Y13 | |
| BOB1 | LLLEEEDSDAyALNHTLS | Y245 | |
| CLNS1A | TEDSIRDyEDGMEVDT | Y214 | |
| HCA59 | NAEDcLyELPENIR | Y147 | |
| Nek9 | LGLDSEEDyYTPQK | Y520 | |
HPK1, mitogen-activated protein kinase kinase kinase kinase 1; BLNK, B-cell linker protein; BTK, bruton tyrosine kinase; GCET2, germinal center B-cell-expressed transcript 2 protein; HS1, hematopoietic lineage cell-specific protein; LAT, linker for activation of T-cells family member 2; PLCG1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; TUBA, tubulin alpha; Syk, spleen tyrosine kinase; MAPRE1, microtubule-associated protein RP/EB family member 1; NUCKS, nuclear ubiquitous casein and cyclin-dependent kinases substrate; BOB1, Pit-Oct-Unc (POU) domain class 2-associating factor 1; CLNS1A, methylosome subunit pICln; HCA59, hepatocellular carcinoma-associated antigen 59; Nek9, NIMA-related kinase 9.