Fig. 5.

Functional consequences of the migration defect in LC in LC/EpCAM-cKO mice. Groups of five LC/EpCAM-cKO (KO) and Cre-negative littermate control (WT) mice were sensitized with 0.5% DNFB on shaved abdomens on day 0 and were challenged with 0.2% DNFB on ear skin on day 5. Negative control WT mice (Vehicle) were sensitized with vehicle and also were challenged with 0.2% DNFB. (Upper) Data represent changes in thicknesses of single ears over baseline at 24 h. (Lower) DNFB-induced ear swelling is shown over 3 d in KO (thick line), WT (thin line), and vehicle-alone control mice (thin broken line). Data represent means ± SEM from three experiments. n = 5 mice per group. *P < 0.001.