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(a) The chemical reaction catalyzed by the organic filament of the sponge spicule. (b) Conservation of residues flanking catalytic serine and histidine in silicatein-α from various sponge species. Shown is the amino acid sequence around the catalytic serine/cysteine and histidine in human cathepsin L (UniProtKB/TrEMBL entry P07711) and silicatein α from: Tethya aurantia (O76238); Suberites domuncula (Q2MEV3); Hymeniacidon perleve (Q2HYF6); Lubomirskia baicalensi (Q2PC18).
