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. Author manuscript; available in PMC: 2012 Apr 16.
Published in final edited form as: J Mol Biol. 2005 May 13;348(4):971–982. doi: 10.1016/j.jmb.2005.02.057

Figure 1.

Figure 1

Figure 1

The mutase enzyme function and structure.

a The chemical reaction catalysed by the mutase enzyme. The cofactor FAD and FADH− are shown. Ring positions numbers are referred to in the text.

b The bicyclic mechanism which does not require direct involvement of the FAD8.

c The redox mechanism in which one electron is transferred to the substrate11. The electron is transferred from FADH- to create a radical which then re-arranges to give product.

d The covalent intermediate mechanism, in the this N5 attacks C1 in a nucleophilic manner. The covalent intermediate then re-arranges to give product. The presence of the covalent intermediate was detected by mass specotrometry12.