Table 1.
Effects of forced expression of ARTEMIN (ARTN) in estrogen receptor (ER) negative mammary carcinoma (ER-MC) cells on expression of genes functionally involved in epithelial-mesenchymal transition (EMT) and metastatic progression
| BT549 | MDA-MB-231 | ||||
|---|---|---|---|---|---|
| Gene Function | Gene | Fold change | p-value | Fold change | p-value |
| Epithelial | CTNNB1 | 0.48 | 1.60E-03 | 0.47 | 1.25E-03 |
| CTNNA1 | 1.3 | 8.71E-03 | 0.68 | 5.80E-04 | |
| CTNNG | 0.52 | 8.23E-03 | 0.46 | 1.58E-02 | |
| OCLN | 0.35 | 9.71E-04 | 0.94 | 2.07E-02 | |
| CDH1 | 0.12 | 4.93E-02 | 0.21 | 4.94E-03 | |
| Mesenchymal | SNAI2 | 1.68 | 6.26E-03 | 1.1 | 1.67E-02 |
| VIM | 2.44 | 9.39E-04 | 1.23 | 6.79E-03 | |
| TWIST1 | 5.49 | 3.98E-03 | 4.56 | 3.99E-03 | |
| SPARC | 1.82 | 2.03E-02 | 2.35 | 6.39E-03 | |
| Metastatic | NME1 | 2.7 | 1.57E-02 | 1.09 | 1.53E-03 |
| PLAU | 1.02 | 4.40E-04 | 0.85 | 1.57E-03 | |
| MMP9 | 2.11 | 3.64E-02 | 0.49 | 1.44E-03 | |
| MET | 0.85 | 1.70E-02 | 0.76 | 3.10E-03 | |
| MMP2 | 1.04 | 2.07E-02 | 4.17 | 1.54E-03 | |
| MTA2 | 3.02 | 8.75E-03 | 1.58 | 1.49E-02 | |
| MMP1 | 1.29 | 4.36E-03 | 0.58 | 2.18E-02 | |
| NFKB1A | 2.23 | 7.19E-03 | 1.02 | 3.49E-03 | |
| NFKB1 | 2.77 | 1.73E-02 | 1.7 | 3.96E-03 | |
| ERBB2 | 1.24 | 1.71E-03 | 0.96 | 5.05E-03 | |
| MYC | 3.55 | 3.97E-04 | 0.95 | 1.40E-03 |
Results are represented as the fold change in messenger RNA (mRNA) levels in BT549-ARTN or MDA-MB-231-ARTN cells relative to the respective VEC cells. Values less than one indicates decreased expression and more than one indicates increased expression of the specific mRNA.