Table 3.
Odds ratio (OR) and 95% confidence interval (CI) adjusted for hormone receptor expression and tumor grading according to cytokines levels in HER+ and HER- patients
| Cytokines level quartiles1 | |||||
|---|---|---|---|---|---|
| 1-low | 2 | 3 | 4-high | P trend | |
| IL-1b | |||||
| N. pos/neg2 | 4/11 | 5/10 | 5/10 | 11/5 | |
| OR (95% CI) | 13 | 6.3 (0.7-53.2) | 33.6 (2.3-494.6) | 55.4 (4.1-746.0) | 0.002 |
| IL-2 | |||||
| N. pos/neg2 | 3/12 | 6/9 | 6/10 | 10/5 | |
| OR (95% CI) | 13 | 15.7 (1.6-150.5) | 10.3 (1.2-92.4) | 31.8 (3.5-289.6) | 0.004 |
| IL-6 | |||||
| N. pos/neg2 | 2/15 | 5/9 | 7/8 | 11/4 | |
| OR (95% CI) | 13 | 3.8 (0.5-31.0) | 8.2 (1.0-65.4) | 21.9 (2.6-185.8) | 0.004 |
| IL-8 | |||||
| N. pos/neg2 | 2/14 | 6/9 | 8/7 | 9/6 | |
| OR (95% CI) | 13 | 3.7 (0.5-26.0) | 5.6 (0.7-42.3) | 11.7 (1.4-95.5) | 0.02 |
| IL-10 | |||||
| N. pos/neg2 | 6/11 | 3/9 | 5/10 | 11/4 | |
| OR (95% CI) | 13 | 0.3 (0.04-2.6) | 1.6 (0.2-12.1) | 9.6 (1.5-59.0) | 0.02 |
1Quartiles were: IL-1b: ≤0.5/0.6-1.7/1.8-4.2/≥4.3; IL-2: ≤2.2/2.3-5.8/5.9-15.8/≥15.9; IL-6: ≤1.6/1.7-3.4/3.5-6.5/≥6.6; IL-8: ≤1.7/1.8-3.7/3.8-6.2/≥6.3; IL-10: ≤0.4/0.5-1.4/1.5-3.3/≥3.4 pg/ml.
2 pos, HER2+; neg, HER2-;
3 Reference category.
HER-2, human epidermal growth factor receptor-2; IL, interleukin.