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Additional TIL subsets and their relationship with CD3 status and anthracycline sensitivity. (a) TIL levels in CD3-high and -low cases. Data represent average numbers of TIL expressing CD8, CD4, or CD20 ±SEM. ***P < 0.0001, Mann-Whitney t test. (b) Association of CD8+ and (c) CD4+ TIL with response to anthracycline therapy. Patients were categorized according to levels of CD8+ and CD4+ TIL and assessed for disease-free survival (DFS) with respect to anthracycline-based therapy.
