Table 2.
Two-sided Fisher's exact tests for association of clinical variables and TIL-signature status with probability of pathological complete response (pCR) in the EORTC cohort
| Total (n = 111) | FEC treated (n = 54) | TET treated (n = 57) | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Size T3 vs T1/T2 | 0.39 (0.17-0.89) | 0.0292 | 0.60 (0.19-1.87) | 0.4103 | 0.25 (0.19-1.87) | 0.0278 |
| Grade 3 vs 1/2 | 2.80 (1.19-6.61) | 0.0226 | 2.35 (0.73-7.56) | 0.1684 | 2.00 (0.58-6.86) | 0.3681 |
| Node 1 vs 0a | 0.82 (0.38-1.78) | 0.6927 | 1.05 (0.34-3.24) | 1.0000 | 0.65 (0.22-1.92) | 0.5823 |
| Age ≥50 vs <50 | 0.89 (0.42-1.89) | 0.8913 | 1.29 (0.43-3.82) | 0.7827 | 0.62 (0.22-1.77) | 0.4311 |
| Her2 A vs Nb | 1.21 (0.52-2.81) | 0.6722 | 2.03 (0.53-7.72) | 0.3243 | 0.81 (0.27-2.46) | 0.7824 |
| TET vs FEC | 1.22 (0.57-2.59) | 0.7022 | NA | NA | NA | NA |
| TIL high vs low | 6.33 (2.49-16.08) | <0.0001 | 6.48 (1.82-23.10) | 0.0035 | 6.84 (1.65-28.39) | 0.0059 |
a1, lymph node positive; 0, lymph node negative. bA, amplified; N, not amplified.