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The effect on NO signaling in endothelial cells challenged by H2O2. The response of EC with regard to NO generation in response to oxidative stress can be divided into two pathways: a physiologic response (right) and a pathologic response (left). The physiologic/pathologic decision is then predicated on the level of H2O2 to which the cell is exposed, the duration of the stimulus, and the ability of the cell to metabolize it.
