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. 2012 Feb 7;3(2):144–157. doi: 10.18632/oncotarget.420

Figure 2. FTS inhibits the growth of subcutaneous GL261 tumors and decreases their downstream Ras proteins and their Foxp3 levels in vivo.

Figure 2

GL261 cells were implanted s.c. in the right flank of C57bl/6 mice, which were then treated for 12 days with oral FTS or vehicle. After the mice were killed the volumes and weights of their excised tumors were recorded, as described previously [31]. (A) Tumor volumes in FTS-treated and control mice are presented as means ± SEM. *, p<0.05, **, p<0.01 compared with control. (B) Tumor weights in FTS-treated and control mice are presented as means ± SEM. *, p<0.05 compared with control. (C) K-Ras, K-Ras-GTP, Erk, P-Erk, Akt, P-Akt, Foxp3 and tubulin in tumors, and Foxp3 and tubulin in splenocytes, of FTS-treated (n=10) and vehicle-treated mice (n=10) were assayed by immunoblotting. Representative blots are shown (top panel). Densitometry values for K-Ras-GTP, P-Erk, P-Akt, and Foxp3 are presented as means ± SEM (bottom panel). *, p<0.05, **, p<0.01, ***, p<0.001 compared with control.