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. 2012 Mar 27;106(8):1446–1452. doi: 10.1038/bjc.2012.95

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Copyright © 2012 Cancer Research UK

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NT5E CpG methylation in cutaneous lesions or LN predicts visceral vs nonvisceral sites of distant metastasis. Pyrosequencing was performed as described in Materials and Methods. The level of methylation is represented by the intensity of shading in the circles, each of which represents an individual CpG dinucleotide in the amplified fragment. The mean % methylation is also shown. The site of biopsy is indicated, together with the site of metastasis: Bl, Bo, Br, Cu, Li, LN, Lu, Or, Pa and ST. Also shown (where available) is the Breslow thickness (BT) of the primary melanoma from which the metastatic lesions derived. The superscripts^1,2,3 denote paired cutaneous biopsies from the same patients. Note that in each case with paired biopsies, the level of methylation is similar in the two biopsies. Abbreviations: Bl=bladder; Bo=bone; Br=brain; Cu=cutaneous; Li=liver; LN=lymph node; Lu=lung; NA=not available; Or=orbit; ST=soft tissue.