Table 3. Sensitivities of FOBTs and blood-based inflammatory markers at given levels specificity for detection of colorectal cancer stratified by stage, location and recruitment setting.
|
Sensitivity at cutoff yielded 97.7% specificity % (95% CI)
|
||||||
|---|---|---|---|---|---|---|
| Number | gFOBT | CRPa | sCD26 | TIMP-1 | iFOBT | |
| Stage | ||||||
| I | 21 | 14.3 (5.0–34.6)b | 9.5 (2.7–28.9) | 0 (0–15.5) | 4.8 (0.8–22.7) | 33.3 (17.2–54.6)b |
| II | 16 | 37.5 (18.5–61.4)b | 12.5 (3.5–36.0) | 0 (0–19.4) | 25 (10.2–49.5) | 75.0 (50.5–89.8)b |
| Advanced stage | 29 | 62.1 (44.0–77.3)b | 31.0 (17.3–49.2) | 0 (0–11.7) | 13.8 (5.5–30.6) | 82.8 (64.5–92.4)b |
| Location | ||||||
| Colon | 40 | 45.0 (30.7–60.2) | 22.5 (12.3–37.5) | 0 (0–8.8) | 17.5 (8.7–32.0) | 55.0 (39.8–69.3)b |
| Rectum | 26 | 30.8 (16.5–50.0) | 11.5 (4.0–29.0) | 0 (0–12.9) | 7.7 (2.1–24.1) | 80.8 (62.1–91.5)b |
| Recruitment setting | ||||||
| Screening setting | 13 | 23.1 (8.2–50.3) | 15.4 (4.3–42.2) | 0 (0–22.8) | 0 (0–22.8) | 69.2 (42.4–87.3) |
| Clinical setting | 54 | 44.4 (32.6–62.0) | 20.4 (11.8–32.9) | 0 (0–6.6) | 16.7 (9.0–28.7) | 64.8 (51.5–76.2) |
Abbreviations: CI=confidence interval; CRP=C-reactive protein; gFOBT=guaiac-based faecal occult blood test; iFOBT=immunochemical faecal occult blood test; sCD26=serum CD26; TIMP-1=tissue inhibitor of metalloproteinases 1.
a
Sensitivity at cutoff yielding 90% specificity.
b
P-value <0.05 by Chi-square or Fisher exact test.