Table 3. Statistical correlations between clinicopathological, immunohistochemical and molecular data for all tumours.
Histological grade | Ductal form | Nuclear grade | Mitosis | Lymph node + | Vascular invasion | |
---|---|---|---|---|---|---|
HR− | 0.080a | 0.024a | NS | 0.091a | NS | NS |
EGFR+ | 0.061 | 0.083 | NS | 0.013 | 0.088 | NS |
αIGF1R+ | 0.001 | NS | 0.07 | 0.004 | NS | 0.005 |
PTEN loss | 0.065 | NS | NS | NS | NS | 0.047 |
PIK3CA mut | NS | NS | 0.043 | NS | NS | NS |
pAkt+ | NS | NS | NS | NS | NS | NS |
pBad+ | 0.001 | NS | 0.008 | 0.002 | NS | 0.006 |
mTOR+ | NS | NS | 0.034 | NS | 0.12 | NS |
MAPK+ | 0.029a | NS | NS | NS | NS | NS |
Ki67 >20% | 0.087 | NS | NS | 0.021 | NS | 0.082 |
p53 >10% | NS | NS | 0.009 | 0.076 | NS | NS |
p27+(nuclear) | NS | NS | NS | NS | NS | NS |
Abbreviations: EGFR=epidermal growth factor 1-receptor; HR=hormonal receptors; IGF1R=insulin-like growth factor 1-receptor; MAPK=mitogen-activated protein kinase; NS=non-significant; PTEN=phosphatase and tensin homologue.
Inverse relationship.