Table 5. Multivariate analysis of histological and biological factors for patients with trastuzumab treatment in the metastatic disease (group A) (Cox model).
| Variables | ß | Hazard ratio | 95% CI | P-value |
|---|---|---|---|---|
| Disease-free survival | ||||
| CNS metastasis | 1.128 | 3.59 | 1.23–10.51 | 0.020 |
| p110α | 1.269 | 2.75 | 1.14–6.49 | 0.024 |
| Overall survival | ||||
| Vascular invasion | 1.17 | 3.36 | 1.22–8.94 | 0.015 |
| CNS metastasis | 1.406 | 4.22 | 1.44–12.38 | 0.009 |
| EGFR | 1.630 | 5.25 | 1.32–20.92 | 0.019 |
Abbreviations: CNS=central nervous system; EGFR=epidermal growth factor 1-receptor.