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. 2012 Mar-Apr;44(2):204–209. doi: 10.4103/0253-7613.93849

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Copyright: © Indian Journal of Pharmacology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of CYP inhibitor and antioxidant on (–)Sch B-induced ROS production in H9c2 cardiomyocytes. 1-aminobenzotriazol (ABT) and dimethylthiouracil (DMTU) were added at final concentrations of 10 mM and 20 mM, respectively, as described in Materials and methods. Respective vehicles were added to drug-untreated cells. Control (CON) group was not treated with ABT or antioxidant. The (–)Sch B (7.5 or 15 μM)-induced ROS production was monitored for 360 min. The extents of ROS production were estimated as described in Materials and methods. Values given are the mean±SD, with triplicate data. # Significantly different from the respective DMSO group (P<0.05)