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. 2012 Mar-Apr;44(2):204–209. doi: 10.4103/0253-7613.93849

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Copyright: © Indian Journal of Pharmacology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of CYP inhibitor and antioxidant pre/co-treatment on (–)Sch B protection against hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes. Cells were pre/co-treated with ABT or DMTU as described in Figure 4. They were exposed to (–)Sch B (15 mM) for 6 h followed by hypoxia/reoxygenation (Hypo/Reoxy) challenge (hypoxia for 2 h and reoxygenation for 16 h) at 16-h post-(–)Sch B exposure. The extent of apoptosis was measured as described in Materials and methods. values given are the mean±SD, with triplicate data. #Significantly differently from the respective non-Hypo/Reoxy group (P<0.05); *significantly different from the respective DMSO-treated Hypo/Reoxy group (P<0.05)