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. Author manuscript; available in PMC: 2012 Sep 2.
Published in final edited form as: Cell. 2012 Feb 23;148(5):922–932. doi: 10.1016/j.cell.2012.01.033

Table 1.

Summary of binding and competition data.

3xmutTLC1-KBS RNA TLC1-KBS RNA Telomeric 3'overhang Random 3'overhang Blunt end
Apparent Kd [nM] 353 ± 49 10.5 ± 0.7 0.17 ± 0.10 0.30 ± 0.22 0.18 ± 0.06
koff [min−1] 2.6 ± 1.2 0.005 ± 0.001 0.011 ± 0.002 0.007 ± 0.005
t1/2 [min] 0.27 140 63 99
kon [M−1S−1] 3.4×106 4.8×105 5.9×105 6.3×105
Ki for TLC1-KBS RNA [nM] 51 ± 32 13 ± 5 19.5 ± 8.3
IC50 for DNA [nM] 40 ± 3 42 ± 9 38 ± 6