Table 1.

Functional annotation clusters of enriched GO biological processes downregulated in the CR skeletal muscle

ES	GO Biological Process	Count	P Value
Cluster 1
3.5	GO:0030029∼actin filament-based process	12	2.2E-05
	GO:0030036∼actin cytoskeleton organization	10	3.3E-04
	GO:0007010∼cytoskeleton organization	14	4.0E-04
Cluster 2
3.0	GO:0006511∼ubiquitin-dependent protein catabolic process	8	2.7E-03
	GO:0043161∼proteasomal ubiquitin-dependent protein catabolic process	5	6.2E-04
Cluster 3
2.8	GO:0044257∼cellular protein catabolic process	18	6.4E-04
	GO:0051603∼proteolysis involved in cellular protein catabolic process	18	7.3E-04
	GO:0043632∼modification-dependent macromolecule catabolic process	17	9.7E-04
	GO:0006508∼proteolysis	23	1.5E-02
Cluster 4
2.2	GO:0044267∼cellular protein metabolic process	49	3.2E-05
	GO:0044260∼cellular macromolecule metabolic process	73	3.8E-02
	GO:0043687∼posttranslational protein modification	22	3.9E-02
Cluster 5
2.1	GO:0014706∼striated muscle tissue development	9	2.5E-04
	GO:0060537∼muscle tissue development	9	4.0E-04
	GO:0007517∼muscle organ development	10	6.3E-04
	GO:0042692∼muscle cell differentiation	7	5.0E-03
	GO:0048747∼muscle fiber development	4	1.3E-02
	GO:0007528∼neuromuscular junction development	3	3.8E-02
Cluster 6
1.3	GO:0042744∼hydrogen peroxide catabolic process	3	1.0E-02
	GO:0070301∼cellular response to hydrogen peroxide	3	1.1E-02
	GO:0000302∼response to reactive oxygen species	4	1.2E-02
	GO:0034599∼cellular response to oxidative stress	3	3.4E-02

An enrichment score (ES) of 1.3 is equivalent to a nonlog scale value of 0.05. Count refers to the gene members that belong to an annotation term. Fisher Exact P value represents the degree of enrichment of the Gene Ontology (GO) term. CR, caloric restriction.