Table 2.

Functional annotation clusters of enriched GO biological processes upregulated in the CR skeletal muscle

ES	GO Biological Process	Count	P Value
Cluster 1
15.5	GO:0006091∼generation of precursor metabolites and energy	32	3.2E-26
	GO:0022900∼electron transport chain	21	8.4E-21
	GO:0055114∼oxidation reduction	33	4.9E-15
Cluster 2
3.6	GO:0015980∼energy derivation by oxidation of organic compounds	10	2.4E-07
	GO:0006119∼oxidative phosphorylation	6	1.5E-04
	GO:0042775∼mitochondrial ATP synthesis coupled electron transport	3	7.0E-03
Cluster 3
3.1	GO:0019752∼carboxylic acid metabolic process	15	3.2E-05
	GO:0006629∼lipid metabolic process	18	2.0E-04
	GO:0006633∼fatty acid biosynthetic process	6	5.1E-04
	GO:0008610∼lipid biosynthetic process	10	1.1E-03
	GO:0046394∼carboxylic acid biosynthetic process	6	5.9E-03
Cluster 4
2.8	GO:0006084∼acetyl-CoA metabolic process	5	1.1E-04
	GO:0009109∼coenzyme catabolic process	4	1.6E-03
	GO:0006732∼coenzyme metabolic process	7	1.9E-03
	GO:0006099∼tricarboxylic acid cycle	3	1.8E-02
	GO:0046356∼acetyl-CoA catabolic process	3	2.0E-02

For abbreviations and definitions, see Table 1 footnote.