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. 2012 Apr 15;23(8):1524–1532. doi: 10.1091/mbc.E11-12-0999

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© 2012 Roth et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Insulin signaling regulates GSC centrosome orientation. (a) Centrosome misorientation frequency upon overexpression of a dominant-negative (K1409A) or a constitutively active form (Del, R418P, or A1325D) of InR using nos-gal4. n > 300/data point. Siblings from the same cross without the nos-gal4 driver served as controls. p values (Student's t test, two-tailed) are provided on each column compared with its control. Statistically significant values (p < 0.01) are highlighted with asterisks. (b) Akt functions downstream of InR in regulating centrosome orientation. n > 300/data point. (c) Local expression of dilp1, 2, 3, 5, and 6 in the testis reduces centrosome misorientation in poor media. Each dilp was expressed in the testis (nos-gal4>UAS-dilp).