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. 2012 Apr 15;23(8):1467–1474. doi: 10.1091/mbc.E12-01-0039

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© 2012 Goeman et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — NF-Y–dependent luciferase transcription in MITO-Luc mice. (a) Scheme of the dominant-negative NF-YA protein (dn-YA). (b) The NF-Y subunits, A, B, and C, form a complex that binds DNA. dn-YA is still able to interact with the NF-YB/-YC dimer, but the resulting trimer is inactive in terms of DNA binding. (c) BLI of representative MITO-Luc mice before (pre) and after (days 2, 4, 6, 8) injection of an adenovirus vector expressing GFP (Ad-GFP) or Ad-dnYA. The experiments were conducted on nine animals per group. Light emitted from the animals appears in pseudocolor scaling. (d) Immunohistochemical analysis of NF-YA, luciferase (LUC), and PCNA in testis (40×; insets: 100×), spleen (100×), and skeletal muscle (60×) tissues from a representative MITO-Luc mouse.