Table 1.

Commonly reported physical side effects of varenicline.

Study	Population	Dosage	Side Effects (including percentage experiencing a given side effect)
Boudrez et al. [56]	Non-psychiatric	Not specified	Nausea (8.9%), insomnia (2.9%), and sleep disorder (2.2%)
Gonzales et al. [57]	Non-psychiatric	1 mg BID	Nausea (28%), insomnia (14%), dry mouth (6.7%), headache (15.5%), and dizziness (6%)
Jorenby et al. [59]	Non-psychiatric	1 mg BID	Nausea (29.4%), insomnia (14.2%), abnormal dreams (13.1%), headache (12.8%), and dry mouth (5.5%)
Nides et al. [61]	Non-psychiatric	1 mg BID	Nausea (52%), insomnia (35.2%), headache (24%), abnormal dreams (15.2%), and taste perversion (15.2%)
Garza et al. [85]	Non-psychiatric	1 mg BID	Nausea (37.7%), insomnia (30.9%), somnolence (20%), and abnormal dreams (9.1%)
Evins and Goff, [88]	Schizophrenia	1 mg BID	Nausea and vomiting (21.1%)
Stapleton et al. [89]	Depression, bipolar disorder, psychosis, psychosis and depression, eating disorders	Not specified	Nausea (32.1%), and sleep disturbances (32.1%)
Smith et al. [90]	Schizophrenia, schizoaffective	1 mg BID	Mild nausea, shaking, dry mouth, and tiredness-sleepiness (57% of all patients experienced at least one side effect)
Weiner et al. [91]	Schizophrenia	1 mg BID	Constipation (50%), insomnia (75%), and nausea (75%)
Liu et al. [92]	Schizophrenia	1 mg BID	Nausea (10%), vomiting (10%), fatigue (5%), dry mouth (5%), muscle stiffness (5%), and headache (5%)
McClure et al. [97]	Depression	1 mg BID	Tension/agitation (51%), nausea (61.6%), sleep disturbance (46.4%), irritability (47.1%), confusion (19.3%), and difficulty concentrating (33.4%)
Philip et al. [98]	Depression	1 mg BID	GI problem (21.4%), sleep disturbances, and irritability (7.1%)
Tonstad et al. [99]	Non-psychiatric	1 mg BID	Sleep disturbance (19.9%)

GI: Gastrointestinal