Table 3. Findings of recent whole-genome association studies.

Disease	Source	Gene/locus	ORhet	ORhom	P value	PAR (%)
Breast cancer	Easton et al55	FGFR2	1.20	1.64	1 × 10−10	16
	Hunter et al56	FGFR2	1.23	1.63	2 × 10−76	—
		TNRC9	1.23	1.39	1 × 10−36	—
		MAP3K1	1.13	1.27	2 × 10−20	—
		LSP1	1.06	1.17	3 × 10−9	—
		8q24	1.06	1.18	5 × 10−12	—
	Stacey et al57	2q35	1.11	1.44	5 × 10−14	14
		TNRC9	1.27	1.64	6 × 10−19	13
Coronary artery disease	McPherson et al58	9p21	1.20	—	4 × 10−6	13
Myocardial infarction	Helgadottir et al59	9p21	1.25	1.64	1 × 10−20	21
Obesity	Frayling et al60	FTO	1.32	1.67	3 × 10−35	20
Diabetes	Sladek et al61	TCF7L2	1.65	2.77	1 × 10−34	28
		SLC30A8	1.18	1.53	6 × 10−8	24
		HHEX	1.19	1.44	3 × 10−6	19
		EXT2	1.25	1.50	1 × 10−4	16
	Steinthorsdottir et al62	CDKAL1	1.25	1.50	8 × 10−9	16
	Scott et al63	IGF2BP1	1.14	—	9 × 10−16	—
		CDKN2A/B	1.20	—	8 × 10−15	—
		11p12	1.25	—	4 × 10−7	—
	Zeggini et al64	KCNJ11	1.14	—	5 × 10−11	—
		PPARG	1.14	—	2 × 10−14	—
Prostate cancer	Yeager et al65	8q24	1.26	1.58	9 × 10−13	21
	Gudmundsson et al66	8q24	1.71	—	2 × 10−14	13

Abbreviations: OR_het, odds ratio – heterozygotes; OR_hom, odds ratio – homozygotes; ‘—', not reported; PAR, population-attributable risk.

Source: Modified from Topol et al.⁴ Copyright © 2007 American Medical Association. All rights reserved.