Table 1.

SNPs with rare alleles in the MTHFR gene of MM subjects categorized by ethnicity

SNP	A1/A2	significance	Caucasian (A1/A2)		Mexican (A1/A2)
			MM	controls	MM	controls
rs3834043	G/-	Intron 1	94/4	No data	94/0	120/0 c
rs45594036	G/T	Intron 1	91/5	114/6 d	92/2	114/6 c
rs13306561	T/C	Intron 1	89/7a	82/24	92/2	109/7
rs2066470	C/T	Pro39Pro	94/4	104/12	93/1	109/5
rs2066466	G/A	Thr139Thr	98/0	No data	92/2	119/1 c
rs1801133	C/T	Ala222Val	58/40a	91/29	43/51	69/47
rs2066462	C/T	Ser352Ser	94/4a	100/14	93/1	113/7 c
rs1994798	T/C	Intron 7	61/37	55/49	74/20	95/25 c
rs12121543	G/T	Intron 7	73/21	87/33	89/5b	96/20
rs1801131	A/C	Glu429Ala	68/26	77/43	87/7b	92/24
rs4846051	T/C	Phe435Phe	92/2	120/0	92/2	113/3
rs17375901	G/A	Intron 9	93/5	113/7	94/0	118/2 c
rs1476413	G/A	Intron 9	77/21	84/36	89/5b	94/22
rs55686944	G/A	Intron 11	90/8	111/9 d	88/4	No data
rs3818762	C/G	Intron 11	78/20	80/36	89/5	113/7 c
rs45622739	G/A	Intron 11	98/0	No data	93/1	120/0 c
rs2274976	G/A	Arg594Gln	98/0a	113/7	93/1	111/5
rs35737219	C/T	Thr653Met	96/2	No data	92/2	120/0 c

Notes: A1/A2 represents alleles 1 and 2 of the SNPs. SNPs and allele counts with significant difference compared to reference population are bolded.

^ap<0.05 comparing Caucasian MM subject to dbSNP Caucasian control allele frequencies.

^bp <0.05 comparing Mexican American MM subject to Mexican American control allele frequencies.

Controls = reference population from dbSNP or other sources include

^ccontrol population data from Martin et al. 2006, and

^dcontrol population data from the 1000 Genome Project.