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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Birth Defects Res A Clin Mol Teratol. 2012 Jan 12;94(2):84–90. doi: 10.1002/bdra.22884

Table 2.

SNPs in the MTHFR gene with significant association with MM

MTHFR SNP Allele A1/A2 Allele frequency A1/A2
MM control p value
Caucasian American
 Intron 1 rs13306561 T/C 0.927/0.073 0.774/0.226 p=0.003
 Exon 5 rs1801133 (Ala222Val)) C/T 0.592/0.408 0.758/0.242 p=0.013
 Exon 7 rs2066462 (Ser352Ser) C/T 0.958/0.042 0.877/0.123 p=0.047
 Exon 12 rs2274976 (Arg594Gln) G/A 1.000/0.000 0.942/0.058 p=0.018
Mexican American
 Intron 7 rs12121543 G/T 0.974/0.053 0.828/0.172 p=0.009
 Exon 8 rs1801131 (Glu429Ala) A/C 0.926/0.074 0.793/0.207 p=0.010
 Intron 10 rs1476413 G/A 0.947/0.053 0.810/0.190 p=0.003

Note: p values – Fisher Exact two-tailed test results.