Table 3. Association of tumor HPV16 positivity of patients with oropharyngeal cancer with combined p73 and p53 variant genotypes.

Combined p53 and p73 variant genotypesa	HPV16+ Patients (N = 230)		HPV16− Patients (N = 79)		Crude OR (95% CI)	Adj. OR (95% CI)b
	No.	%	No.	%
Low-risk group	72	31.3	41	51.9	1.0 (ref.c)	1.0 (ref.c)
Medium-risk group	109	47.4	29	36.7	2.1 (1.2–3.8)	2.4 (1.3–4.2)
High-risk group	49	21.3	9	11.4	3.1 (1.4–7.0)	3.2 (1.4–7.4)
Trend test					P = 0.001	P = 0.001

^aLow-risk group: individuals with p53 Arg/Arg and p73 GC/GC genotypes; Medium-risk group: individuals with p53 Arg/Arg and p73 AT carriers or p53 Pro carriers and p73 C/GC; and High-risk group: individuals with p53 Pro carriers and p73 AT carriers.

^bORs were adjusted for age, sex, ethnicity, smoking, and alcohol use in a logistic regression model.

^cReference group.