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. 2012 Apr 16;7(4):e35423. doi: 10.1371/journal.pone.0035423

Figure 7. Regulatory loops identified through the combination of miRNA, mRNA and protein expression levels.

Figure 7

Panel A. Coherent regulatory loops: up/down miRNA regulating the target mRNA through degradation. Panel B. Incoherent regulatory loops: an up/down miRNA regulating the protein level through translational repression. Panel C. Incoherent regulatory loops: an up/down miRNA whose effect is not sufficient to overcome the effect of another external signal and thus it is impossible to hypothesize if miRNA acts as mRNA degradation or translational repressor.