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. 2012 Apr 16;7(4):e35423. doi: 10.1371/journal.pone.0035423

Table 2. Pathways enrichment analysis within up and downregulated genes using KEGG and Metacore databases.

Database Name Adj p-value Expression 402-91/ET vs 402-91
KEGG NOD-like receptor signaling pathway 0,01 up
KEGG Small cell lung cancer 0,03 up
KEGG Vitamin B6 metabolism 0,05 up
KEGG p53 signaling pathway 0,05 up
KEGG PPAR signaling pathway 0,05 up
Metacore Immune response_IL-17 signaling pathways 0 up
Metacore Immune response_Alternative complement pathway 0 up
Metacore Cytokine production by Th17 cells in CF 0,00021 up
Metacore Cell cycle_Regulation of G1/S transition (part 1) 0,00023 up
Metacore Cell cycle_Regulation of G1/S transition (part 2) 0,0006 up
Metacore Development_TGF-beta-dependent induction of EMT via MAPK 0,0007 up
Metacore Cytokine production by Th17 cells in CF (Mouse model) 0,00085 up
Metacore Cell cycle_Nucleocytoplasmic transport of CDK/Cyclins 0,00122 up
Metacore Development_TGF-beta-dependent induction of EMT via SMADs 0,00256 up
Metacore Immune response_Th17-derived cytokines 0,00262 up
Metacore Development_PEDF signaling 0,00361 up
Metacore Cytoskeleton_Regulation of cytoskeleton rearrangement 0,00381 up
KEGG Focal adhesion 0,001 down
KEGG Notch signaling pathway 0,002 down
KEGG Prion diseases 0,003 down
KEGG ECM-receptor interaction 0,007 down
KEGG Lysosome 0,01 down
KEGG Gap junction 0,011 down
KEGG Axon guidance 0,012 down
KEGG Inositol phosphate metabolism 0,015 down
KEGG Bladder cancer 0,03 down
KEGG Tight junction 0,033 down
KEGG Neurotrophin signaling pathway 0,034 down
KEGG Insulin signaling pathway 0,035 down
KEGG Valine, leucine and isoleucine degradation 0,038 down
KEGG Chronic myeloid leukemia 0,044 down
KEGG Endocytosis 0,044 down
KEGG N-Glycan biosynthesis 0,047 down
KEGG Adherens junction 0,051 down
Metacore Cell adhesion_Amyloid proteins 0 down
Metacore Immune response_Histamine signaling in dendritic cells 0,00001 down
Metacore Signal transduction_cAMP signaling 0,00001 down
Metacore Development_S1P2 and S1P3 receptors in cell proliferation and differentiation 0,00001 down
Metacore Development_Blood vessel morphogenesis 0,00001 down
Metacore Development_Notch Signaling Pathway 0,00002 down
Metacore Development_A2A receptor signaling 0,00002 down
Metacore Blood coagulation_GPCRs in platelet aggregation 0,00002 down
Metacore Cell adhesion_Platelet aggregation 0,00002 down
Metacore Cytoskeleton_Actin filaments 0,00002 down
Metacore Development_Neurogenesis_Axonal guidance 0,00006 down
Metacore Development_A2B receptor: action via G-protein alpha s 0,00008 down
Metacore Signal transduction_Activation of PKC via G-Protein coupled receptor 0,00012 down
Metacore Transcription_CREB pathway 0,00013 down
Metacore PGE2 pathways in cancer 0,00018 down
Metacore Signal Transduction_Cholecystokinin signaling 0,00052 down
Metacore Cytoskeleton_Regulation of cytoskeleton rearrangement 0,00105 down
Metacore Muscle contraction_Nitric oxide signaling in the cardiovascular system 0,00197 down
Metacore Development_Hedgehog signaling 0,00287 down
Metacore Cell adhesion_Leucocytechemotaxis 0,00747 down