Table 4. Gene Ontology categories and KEGG, PANTHER and Metacore pathway enrichment analysis within up and down regulated proteins.

Category	Name	p-value	Expression 402-91/ET vs 402-91
GeneOntology
GO	apoptosis	0,00000	up
GO	programmedcelldeath	0,00000	up
GO	celldeath	0,00000	up
GO	cellular component organization	0,00000	down
GO	cellular component organization or biogenesis	0,00000	down
GO	cellular component organization at cellular level	0,00000	down
Pathway
KEGG	hsa04115:p53 signalingpathway	0,00027	up
KEGG	hsa04210:Apoptosis	0,00140	up
KEGG	hsa05219:Bladder cancer	0,00397	up
KEGG	hsa05218:Melanoma	0,04945	up
KEGG	hsa05212:Pancreatic cancer	0,05277	up
KEGG	hsa04010:MAPK signalingpathway	0,07292	up
KEGG	hsa05200:Pathways in cancer	0,07840	up
KEGG	hsa04650:Natural killer cell mediated cytotoxicity	0,14232	up
PANTHER	P00006:Apoptosis signalingpathway	0,00052	up
PANTHER	P00059:p53 pathway	0,01579	up
Metacore	Apoptosis and survival_p53-dependent apoptosis	0	up
Metacore	Apoptosis_Death Domain receptors &caspases in apoptosis	0	up
Metacore	Cell adhesion_Amyloid proteins	0	up
Metacore	Cell cycle_G1-S Growth factor regulation	0,00001	up
Metacore	Apoptosis and survival_Role of IAP-proteins in apoptosis	0,00026	up
Metacore	Translation _Regulation of EIF2 activity	0,00084	up
KEGG	hsa04110:Cell cycle	0,00000	down
KEGG	hsa05200:Pathways in cancer	0,00235	down
KEGG	hsa04510:Focal adhesion	0,00681	down
KEGG	hsa04210:Apoptosis	0,01537	down
KEGG	hsa05212:Pancreatic cancer	0,03870	down
PANTHER	P00006:Apoptosis signalingpathway	0,00022	down
PANTHER	P00020:FAS signalingpathway	0,00130	down
Metacore	Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling	0,00000	down
Metacore	Signaltransduction_AKTsignaling	0,00000	down
Metacore	Cytoskeletonremodeling_Cytoskeletonremodeling	0,00000	down
Metacore	Cell cycle_G1-S Growth factor regulation	0,00000	down
Metacore	Cell cycle_G1-S Interleukin regulation	0,00001	down
Metacore	Cell cycle_Core	0,00015	down