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. Author manuscript; available in PMC: 2012 Aug 24.
Published in final edited form as: Mol Cell. 2012 Feb 24;45(4):483–493. doi: 10.1016/j.molcel.2011.11.035

Figure 1. Extrinsic versus intrinsic noise decomposition across the proteome.

Figure 1

(a) Histograms of the single cell fluorescence of populations of cells expressing either one (red) or two (blue) copies of pGal1-YFP. The mean of the two distributions are separated by one log2 unit.

(b) Total, intrinsic, and extrinsic noise plotted against log mean expression for seven levels of induction of pGal1-YFP. Noise was quantified as the Coefficient of Variation (CV=σ/μ) of the YFP distribution.

(c) Comparison of extrinsic noise values calculated using a two color (pGal1-YFP, pGal1-mCherry) or one color approach.

(d) Intrinsic (cyan) and extrinsic(black) noise plotted against log2 mean expression for 465 genes. Inset: log2(CV2) plotted against log2(mean), running means (smoothing window of 30) for intrinsic(cyan), extrinsic(black), total (dark blue) noise.