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Total (A) and unconjugated (B) MD concentrations in urine of untreated male Fischer 344 rats and those fed 1.6mg L-PK /kg diet for 1 or 7d. Urine total MD concentrations include both conjugated and unconjugated forms. Values are means ± SD, n = 5. Labeled means for a variable without a common letter differ, P < 0.017 (Wilcoxon rank sum test). C, control; L-PK, deuterium-labeled phylloquinone; MD, menadione; PK-1d, fed 1 d of 1.6 mg L-PK/kg diet; PK-7d, fed 7 d of 1.6 mg L-PK/kg diet.
