Figure 5. Morphology, area and actin structures change significantly in CD34+ cells changes with differentiation.
(A) Multipotent CD34+ cells show poorly organized actin (green) and a nucleus (blue) which occupies most of the cell volume. (B–C) With differentiation, cells show developed actin stress fibers and enlargement. (D) With differentiation the cell area increases, but the nuclear area decreases (p<0.002), suggesting cytoskeletal reorganization and stiffening of the cell. Scale is 25 µm. Errors are SEM.